The Nexus is intended to be the hub of the Andromeda Initiative once the project reaches the Andromeda galaxy. Taking inspiration from the much larger Citadel, the Nexus contains features comparable in form and function to those found in the Milky Way station and houses the command echelons of the project. Once completed the NEXUS will have living space for about 25 million.

Station name: Nexus
Length: 15.47km (when completed)
Anchorage wheel diameter: 5.3km
Status: Under construction

At launch, the Nexus resembles two Wards of the Citadel joined together at the base. Upon reaching Andromeda, construction is due to commence on the station in order to give it a Presidium-like central torus and another Ward-like superstructure. The arks are to dock with the station on its central support column to provide it with extra power and storage.

The Nexus was activated a year before the Hyperion arrived in Andromeda. With its original leadership decimated in the Scourge Disaster shortly after arrival, and unable to establish contact with any of the First Wave Arks, the staff on board began having disputes, this eventually led to a rebellion against the Nexus leaders, after this conflict the crew on board who had rebelled were banished from the Nexus and labeled as "Exiles". There has also been reports of terrorist activity and sabotage from other crew members who did not agree with the senior staff on topics of survival within the Andromeda Galaxy. The krogan who were originally part of the Nexus team had been told by the Nexus leaders that if they stopped the rebels they would be given more control over what happens on the Nexus, however they were not given anything for their efforts, and so nearly all the krogan left to form their own colony.

Furthermore, with 2 attempts at establishing outposts both ended in disaster, run-ins with the hostile Kett, and without the resources and manpower supposedly to be provided by the Arks, couple with food shortages, the standing Nexus leadership were forced to cease all construction on the Nexus, and stretch their dwindling food stores via rationing.

By the time of approximately fourteen months after the Nexus' arrival, even its inhabitants began to give up all hope of rendezvousing with the other arks. That all changes when Hyperion arrives and docks with the station. Despite the Nexus leadership's uncertainty with the success of Pathfinder Ryder, the station itself slowly began working to revitalize the Initiative, culminating in the successful settlement of Eos and subsequent first contact with the angara.